ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain
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چکیده
منابع مشابه
Modelling activity - dependent changes of axonal spike 1 conduction in primary afferent C - nociceptors
Jenny Tigerholm, Marcus E. Petersson, Otilia Obreja, Angelika Lampert Richard 3 Carr Martin Schmelz, Erik Fransén 4 1 Dept. of Computational Biology, School of Computer Science and Communication, KTH 5 Royal Institute of Technology, Stockholm, Sweden 6 2 Stockholm Brain Institute, KTH Royal Institute of Technology, Stockholm, 7 Sweden 8 3 Dept. of Anaesthesiology Mannheim, Heidelberg University...
متن کاملModeling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors.
Action potential initiation and conduction along peripheral axons is a dynamic process that displays pronounced activity dependence. In patients with neuropathic pain, differences in the modulation of axonal conduction velocity by activity suggest that this property may provide insight into some of the pathomechanisms. To date, direct recordings of axonal membrane potential have been hampered b...
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Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats.
Diabetic neuropathic pain is often considered to be caused by peripheral neuropathy. The involvement of the CNS in this pathological condition has not been well documented. Development of hypersensitivity of spinal dorsal horn neurons is involved in neuropathic pain induced by traumatic nerve injury. In the present study, we determined the functional changes of identified spinothalamic tract (S...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2020
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2020.104961